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The Transforming Pharma Landscape
In the past century, scientific breakthroughs and economic development enabled pharmaceutical firms to seize the opportunity of providing medical treatment for a range of ailments varying from microbial infections to genetic disorders. Aside from research and development (R&D)-focused pharmaceutical firms, even generic companies benefited from the ever-increasing demand for affordable medicines. Until the last decade, with scope for differentiation, R&D was both feasible and affordable and the industry grew exponentially.
The Indian pharmaceutical sector, primarily comprising generic firms, also performed well above market average. Figure 1 compares the NIFTY 50 and NIFTY Pharma from January 2010 till May 2018 in India. A head-to-head comparison highlights the superior performance of the pharma Index over NIFTY, especially before 2015. The post-2015 trajectory merits more discussion below.
However, the contribution of the pharmaceutical sector has gone beyond profit-making. During 2002 to 2012, generic firms also played a significant role in lowering drug prices for diseases like HIV and in increasing access (Check Hayden 2014).
However, with increasing pricing regulation aimed at improving healthcare access, pricing turned competitive and multiple companies started targeting the same disease conditions. The effect was quite evident on Indian pharmaceuticals too. They saw a steady decline in margins, from 2015 onwards, as Figure 1 suggests. The gradual increase in competition and complexity of ailments, coupled with declining margins, turned both the feasibility and cost of drug discovery and development into a challenge.
Some of the major incumbents initially sought to overcome these challenges through major acquisitions and consolidation. However, the underlying issues remained. A few major paths remain available to pharmaceutical firms. Among these are a differentiation route or a cost leadership route. The former requires work with rare diseases that defy economic feasibility considerations for R&D investment. The latter focuses on improving market penetration of existing drugs.
[This article has been reproduced with permission from the Indian School of Business, India]